Abstract EN:

The realisation of ditopic molecular receptors derived from calix[6]arenes has been studied according to three different methodologies. The formation, thnaks to cooperative and allosteric processes, of sophisticated hetero self-assembled receptors has been achieved. The originality of theses edifices stands in the fact that the processes are directed by the inclusion of the guests, thus increasing the preorganisation degree of the hosts and directionnality of the interactions between the sub-units. [1+1] macrocyclisation reactions have led efficiently to new calix[6]azacryptands and calix[6]azatubes. Endo-complexation of the guests was accomplished through induced fir processes according to two new original modes of recogintion, thus leading to multitopic receptors. A calix[6]arenic key intermediate possessing three of the six amino groups regioselectively protexted have been obtained quantitatively, conducting to the first ditopic calix[6]azacryptand able to perform ion pair recognition.