Abstract FR:

Cette these met en valeur la performance d'une approche multivariee pour (i) l'analyse des resultats obtenus dans un systeme de criblage qui mesure les affinites relatives de nombreux steroides pour 5 recepteurs et (ii) la stratification et classification de plusieurs recepteurs nucleaires, ainsi que des inhibiteurs des proteases a serine, sur la base de leurs composition en acides amines. Elle est basee sur 7 articles publies ou acceptes. 1. Ojasoo t. And raynaud j. P. Unique steroid congeners for receptor studies. Cancer res. 38,4186-4198, 1978. 2. Ojasoo t. , dore j. C. , gilbert j. And raynaud j. P. Binding of steroids to the progestin and glucocorticoid receptors analyzed by correspondence analysis. J. Med. Chem. 31, 1160-1169, 1988. 3. Ojasoo t. , dore j. C. , mornon j. P. And raynaud j. P. Two approaches to structure-activity relationships in the field of sex-steroids and their analogs. In: molecular structure and biological activity of steroids (m. Bohl and w. L duax. , eds), crc press, boca raton, pp. 157-207, 1992. 4. Ojasoo t. , raynaud j. P. And dore j. C. Affiliations among steroid receptors as revealed by multivariate analysis of steroid binding data. J. Steroid biochem. Mol. Biol. 48, 31-46, 1994. 5. Ojasoo t. , raynaud j. P. And dore j. C. Correspondence factor analysis of steroid libraries. Steroids 60, 458-469, 1995. 6. Ojasoo t. Multivariate preclinical evaluation of progestins. Menopause 2, 97-107, 1995