Abstract EN:

This work deals with an analysis of the research projects in a big pharmaceutical laboratory. In this thesis, we propose an examination of different projects of research (fundamental research). This work is built in two parts. At first, we detail the internal conditions of evaluation of the projects (pre-molecules, financial allocations process) in a big pharmaceutics laboratory. We are insisting more particularly on the conditions of production of fundamental knowledge. We are more specifically interested in the tools of evaluation used by administrators, accountants and the scientific management to validate or push aside the projects of research. In the second part, we propose different models of estimation of the projects of research (model with and without memory) and a microeconomic study of the impact of the news on the volatility of the prise on stock exchange (GARCH and E-Garch multivariate model) based on Sanofi's volatily. We tend to demonstrate the existence of a short-termist model of evaluation.